Bioactive nanocomposite hydrogel with synergistic antibacterial and cytoprotective functions: Multi-target keratinocyte modulation for infected wound regeneration

文献类型： 外文期刊

第一作者： Zhou, Enning

作者： Zhou, Enning;Zhu, Yuying;Zhao, Liuwei;Wang, Miao;Wu, Liming;Li, Qiangqiang;Chen, Gang;Liu, Dongyuan

作者机构：

关键词： Bacterial infected wound healing; Carbon dots; Multifunctional hydrogels; Royal jelly and honey; Bioactive nanomaterials

期刊名称：CHEMICAL ENGINEERING JOURNAL （ 影响因子：13.2； 五年影响因子：13.5 ）

ISSN： 1385-8947

年卷期： 2025 年 520 卷

页码：

收录情况： SCI

摘要： Pathogenic bacterial infections are responsible for one-eighth of global mortality, with Staphylococcus aureusinduced wound infections serving as a critical example that presents significant challenges due to antibiotic resistance and impaired tissue regeneration. To address this issue, we innovatively synthesized 10-hydroxy-2decenoic acid-functionalized carbon dots (10-HDA@CDs) using bioactive royal jelly derivatives and further incorporated them into a honey-reinforced alginate-dopamine hydrogel (10-HDA@CDs@HON/SA-DA). The resultant composite hydrogel demonstrated synergistic antibacterial efficacy, achieving over 99.9 % clearance of S. aureus. In vivo studies revealed accelerated healing of infected wounds through mechanisms including inflammation inhibition, promotion of myofibroblasts proliferation, and enhanced angiogenesis. Single-cell transcriptomics unveiled the multi-cytoprotective mechanism of 10-HDA@CDs@HON/SA-DA hydrogel against S. aureus pathogenesis by suppressing chronic inflammation, oxidative stress, and DNA damage, while enhancing keratinocyte functions to expedite infected wound healing. This work pioneers a "nano-bio" therapeutic strategy with three key innovations: integrating natural bioactive molecules with nanomaterials; modulating the multitarget crosstalk between infection and microenvironment; and accelerating antibiotic-free healing via keratinocyte phenotypic restoration. Our findings validate natural food-derived nanomaterials as high-safety and sustainable alternatives for integrated wound management, paving the way for multifunctional nanotherapeutics in precision dermatology.

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