Matrix metalloproteinase 7 (MMP7) as a molecular target for Mycoplasma gallisepticum (MG) resistance in chickens
文献类型： 外文期刊
第一作者： Li, Shiying
作者： Li, Shiying;Zou, Mengyun;Wang, Yingjie;Guo, Qiao;Lv, Shan;Zhao, Wenqing;Kabir, Md. Ahsanul;Peng, Xiuli;Li, Shiying;Zou, Mengyun;Wang, Yingjie;Guo, Qiao;Lv, Shan;Zhao, Wenqing;Kabir, Md. Ahsanul;Peng, Xiuli;Li, Shiying;Zou, Mengyun;Wang, Yingjie;Guo, Qiao;Lv, Shan;Zhao, Wenqing;Kabir, Md. Ahsanul;Peng, Xiuli;Zou, Mengyun;Wang, Yingjie
作者机构：
关键词： MMP7; Disease-resistant breeding; Chicken
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）
ISSN： 0141-8130
年卷期： 2025 年 298 卷
页码：
收录情况： SCI
摘要： Mycoplasma gallisepticum (MG) causes chronic respiratory disease (CRD), posing a significant threat to global poultry production. Current preventive strategies face limitations, emphasizing the need for alternative approaches such as breeding for disease resistance. This study identifies the matrix metalloproteinase 7 (MMP7) gene as a key factor in CRD resistance. Analysis of high-throughput sequencing data revealed MMP7's association with MG infection at tissue and cellular levels. Overexpression of MMP7 in avian type II alveolar epithelial cells (AECII) and macrophages (HD11) inhibited MG adhesion, modulated immune responses, and suppressed MGinduced cell proliferation and apoptosis, though MG replication remained unaffected. Conversely, MMP7 inhibition enhanced MG infection. Experimental infections in commercial (Jingfen Layer No.6, Hy-Line White) and local Chinese chicken breeds (Guangxi Indigenous, Tianlu Partridge, Cyan Shank Partridge) validated Tianlu Partridge chickens' relative resistance and Jingfen Layers' susceptibility. MMP7 expression levels correlated positively with reduced chick weight, air sac damage, tracheal mucosal thickness, and MG lung loads. These findings highlight MMP7 as a molecular target for assessing MG susceptibility and breeding resistant chickens while demonstrating the utility of local Chinese breeds in resistance-focused breeding programs.
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