Regulation of litter size in sheep (Ovis aries) by the GDF9 and BMP15 genes

文献类型： 外文期刊

第一作者： Chen, Yang

作者： Chen, Yang;Shan, Xuesong;Jiang, Huaizhi;Sun, Limin;Guo, Zhenhua

作者机构：

关键词： Ewe; Follicle; Lambing size; Meta-analysis; Protein docking

期刊名称：ANNALS OF AGRICULTURAL SCIENCES （ 影响因子：5.9； ）

ISSN： 0570-1783

年卷期： 2023 年 68 卷 2 期

页码：

收录情况： SCI

摘要： The mutation types GDF9 S395F and S427R increase the ovulation rate in heterozygotes, while the homozygous form leads to infertility. This study presents a meta-analysis of GDF9 and BMP15 SNPs related to sheep litter size (LS). The results showed that simulation of the molecular recognition of GDF9 R453H, S395F, and S427R was per-formed to study the effect on the GDF9 dimer. S395F and S427R dimer binding ability of mutant heterozygotes was improved, thereby improving LS. The binding ability of mutant homozygous dimers was reduced, resulting in infertility. The results of this study will provide important references for animal breeding.(c) 2023 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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