Metabolic Profile of Nitazoxanide in Goat Feces

文献类型： 外文期刊

第一作者： Zhao, Zhanzhong

作者： Zhao, Zhanzhong;Zhang, Lifang;Xue, Feiqun;Zhang, Tao

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关键词： Column liquid chromatography-mass spectrometry;Nitazoxanide

期刊名称：CHROMATOGRAPHIA （ 影响因子：2.044； 五年影响因子：1.725 ）

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收录情况： SCI

摘要： A sensitive and specific method for the identification of nitazoxanide metabolites in goat feces by liquid chromatography-electrospray ionization tandem mass spectrometry with negative ion mode was developed. After extraction procedure the pretreated samples were injected on an XTerra MS C8 column with mobile phase (0.2 mL min(-1)) of acetonitrile and 10 mM ammonium acetate (adjusted to pH 2.5 with formic acid) followed by a linear gradient elution, and detected by MS-MS. Identification and structural elucidation of the metabolites were performed by comparing their retention times (R-t), full scan, product ion scan, precursor ion scan and neutral loss scan MS-MS spectra to those of the parent drug or other available standard. The parent drug (nitazoxanide) and its deacetyl metabolite (tizoxanide) were found in goat feces after the administration of a single oral dose of 200 mg kg(-1)of nitazoxanide. Tizoxanide was detected in goat feces for up to 96 h after ingestion of nitazoxanide.

分类号： O65

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