Gene expression response to Salmonella Typhimurium in the cecal tonsil reveals a potential mechanism of resistance in chickens

文献类型： 外文期刊

第一作者： Zhang, Qi

作者： Zhang, Qi;Liu, Yuhong;Zhang, Jin;Wang, Qiao;Wen, Jie;Zhao, Guiping;Li, Qinghe;Ying, Fan;Liu, Dawei

作者机构：

关键词： chicken; Salmonella; cecal tonsil; disease resistance; gene expression

期刊名称：POULTRY SCIENCE （ 影响因子：4.4； 五年影响因子：4.4 ）

ISSN： 0032-5791

年卷期： 2024 年 103 卷 3 期

页码：

收录情况： SCI

摘要： Salmonella has been one of the most important factors restricting the development of the poultry industry and also poses great threat to public health. To get insight into molecular alterations that occur during bacterial infection, we sequenced the cecal tonsil transcriptome in 2 chicken breeds (Beijing -You and Cobb) known to have differing resistance to Salmonella. The 28 -day -old chickens were orally challenged by 1.83 x 10(11) CFU Salmonella Typhimurium, and the cecal tonsil transcriptome was sequenced 3 d postinfection. Analysis identified 201 and 170 differentially expressed genes response to Salmonella in 2 chicken breeds, respectively. They were involved in the Toll -like receptor signaling pathway and activated the production of pro-inflammatory cytokines and chemokines. The protein-protein interaction (PPI) network suggested MMP9 as a crucial protein that may be involved in extracellular matrix breakdown and leukocyte migration in the resistant breed (Beijing -You). Meanwhile, in susceptible chickens (Cobb), ACOD1 was the key gene in the PPI network and might promote the expression of genes related to oxidative stress response and gastrointestinal tract function. These findings provide insight into the differing resistance of these 2 chicken breeds.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序