The Toxicity, Sublethal Effects, and Biochemical Mechanism of beta-Asarone, a Potential Plant-Derived Insecticide, against Bemisia tabaci

文献类型： 外文期刊

第一作者： Wang, Ran

作者： Wang, Ran;Zhang, Qinghe;Luo, Chen;Fang, Yong;Che, Wunan;Wang, Jinda

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关键词： Bemisia tabaci; whitefly; beta-asarone; plant-derived toxin; sublethal effects; metabolic enzymes; cytochrome P450 monooxygenases

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：6.208； 五年影响因子：6.628 ）

ISSN：

年卷期： 2022 年 23 卷 18 期

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收录情况： SCI

摘要： Bemisia tabaci is a threat to agriculture worldwide because of its potential to cause devastating damage to various crops. beta-asarone is a bioactive pesticidal chemical originating from Acorus calamus (or "Sweet Flag") plants, and it displays significant lethal effects against insect pests. In this study, we established a baseline of susceptibility to beta-asarone from China and patterns of cross-resistance to other popular insecticides. We found that all the 12 field-collected B. tabaci populations exhibited high susceptibility to beta-asarone, and there was no cross-resistance detected for other tested insecticides. We subsequently evaluated the sublethal effects of beta-asarone on physiology and biochemistry via LC25 treatment (4.7 mg/L). LC25 of beta-asarone resulted in prolonged developmental duration and decreased survival rates in B. tabaci nymphs, pseudopupae, and adults. Significant reductions in oviposition duration, fecundity, and hatchability were also observed. Additionally, the metabolic enzyme activity and expression profiles of selected cytochrome P450 monooxygenase (P450) genes following the LC25 treatment of beta-asarone suggest that enhanced detoxification via P450s could be involved in the observed sublethal effects. These findings demonstrate the strong toxicity and significant sublethal effects of beta-asarone on B. tabaci and suggest that the induced overexpression of P450 genes could be associated with the response to beta-asarone.

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