Epitranscriptional regulation of TGF-β pseudoreceptor BAMBI by m6A/YTHDF2 drives extrinsic radioresistance
文献类型： 外文期刊
第一作者： Wang, Liangliang
作者： Wang, Liangliang;Piffko, Andras;Bugno, Jason;Yang, Kaiting;Wen, Chuangyu;Chen, Dapeng;Huang, Xiaona;Wang, Jiaai;Arina, Ainhoa;Pitroda, Sean;Chmura, Steven J.;Liang, Hua Laura;Weichselbaum, Ralph;Wang, Liangliang;Piffko, Andras;Bugno, Jason;Yang, Kaiting;Wen, Chuangyu;Chen, Dapeng;Huang, Xiaona;Wang, Jiaai;Arina, Ainhoa;Pitroda, Sean;Liang, Hua Laura;Weichselbaum, Ralph;Si, Wei;Yu, Xianbin;Dou, Xiaoyang;Zhang, Linda;He, Chuan;Yu, Xianbin;Dou, Xiaoyang;Zhang, Linda;He, Chuan;Yu, Xianbin;Dou, Xiaoyang;Zhang, Linda;He, Chuan;Piffko, Andras;Ding, Xingchen;Bugno, Jason;He, Chuan;Wang, Liangliang;Liang, Hua Laura;Weichselbaum, Ralph
作者机构：
期刊名称：JOURNAL OF CLINICAL INVESTIGATION （ 影响因子：15.9； 五年影响因子：16.7 ）
ISSN： 0021-9738
年卷期： 2023 年 133 卷 24 期
页码：
收录情况： SCI
摘要： Activation of TGF-beta signaling serves as an extrinsic resistance mechanism that limits the potential for radiotherapy. Bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) antagonizes TGF-beta signaling and is implicated in cancer progression. However, the molecular mechanisms of BAMBI regulation in immune cells and its impact on antitumor immunity after radiation have not been established. Here, we show that ionizing radiation (IR) specifically reduces BAMBI expression in immunosuppressive myeloid-derived suppressor cells (MDSCs) in both murine models and humans. Mechanistically, YTH N6-methyladenosine RNA-binding protein F2 (YTHDF2) directly binds and degrades Bambi transcripts in an N6-methyladenosine-dependent (m6A-dependent) manner, and this relies on NF-KB signaling. BAMBI suppresses the tumor-infiltrating capacity and suppression function of MDSCs via inhibiting TGF-beta signaling. Adeno-associated viral delivery of Bambi (AAV-Bambi) to the tumor microenvironment boosts the antitumor effects of radiotherapy and radioimmunotherapy combinations. Intriguingly, combination of AAV-Bambi and IR not only improves local tumor control, but also suppresses distant metastasis, further supporting its clinical translation potential. Our findings uncover a surprising role of BAMBI in myeloid cells, unveiling a potential therapeutic strategy for overcoming extrinsic radioresistance.
分类号：
- 相关文献
作者其他论文 更多>>
-
18Beta-Glycyrrhetinic Acid Attenuates H2O2-Induced Oxidative Damage and Apoptosis in Intestinal Epithelial Cells via Activating the PI3K/Akt Signaling Pathway
作者：Ma, Cui;Wang, Fuxi;Zhu, Jiawei;Wang, Shiyi;Liu, Yaqing;Xu, Jianfang;Zhao, Qingyu;Qin, Yuchang;Si, Wei;Zhang, Junmin;Wang, Fuxi;Wang, Shiyi;Liu, Yaqing
关键词：18beta-glycyrrhetinic acid; oxidative stress; PI3K/Akt pathway; molecular docking
-
A novel nucleic acid linker for multi-gene expression enhances plant and animal synthetic biology
作者：Ma, Xuhui;Yue, Qun;Miao, Liqing;Li, Suzhen;Zhang, Liwen;Yang, Wenzhu;Zhou, Xiaojin;Chen, Rumei;Xu, Yuquan;Liu, Xiaoqing;Tian, Jian;Si, Wei;Zhang, Junmin
关键词：nucleic acid linker; multi-gene expression; gene stacking; synthetic biology; astaxanthin
-
Actinoplanes sandaracinus sp. nov., a novel ligninase- producing and cellulose- degrading actinobacterium isolated from soil
作者：Wang, Zishan;Xu, Yan;Zhou, Changjian;Sun, Xiujun;Huang, Zhenzhen;He, Chuan;Yao, Siqi;Zhao, Junwei;Wang, Xiangjing;Song, Jia;Xiang, Wensheng;Xiang, Wensheng
关键词：16S rRNA gene; genome characterization; novel species; taxonomy
-
Microbial and Metabolic Profiling of Obese and Lean Luchuan Pigs: Implications for Phenotypic Divergence
作者：Zhu, Lihui;Tu, Weilong;Ma, Shengwei;He, Chuan;Bai, Lan;Wu, Xiao
关键词：phenotypic differentiation; gut microbiome; metabolomics; SCFAs
-
Mutations at site 207 of influenza a virus NS1 protein switch its function in regulating RIG-I-like receptors mediated antiviral responses
作者：Wang, Xingbo;Lin, Lulu;Si, Wei;Yan, Yan;Dong, Weiren;Jin, Yulan;Zhou, Jiyong;Chen, Zhen;Si, Wei;Huang, Yu;Zhou, Jiyong;Zhou, Jiyong
关键词：IFI35; RIG -I -like receptors; Influenza a virus; NS1; RNA recognition; K48-linked ubiquitination
-
A rapid and high-throughput system for the detection of transgenic products based on LAMP-CRISPR-Cas12a
作者：Liu, Hua;Zeng, Haijuan;He, Chuan;Wang, Jinbin;Cheng, Fang;Tang, Xueming;Tang, Xueming
关键词：GM organisms; CRISPR-Cas12a; LAMP; Rapid detection
-
Plant growth-promoting rhizobacteria Bacillus velezensis JB0319 promotes lettuce growth under salt stress by modulating plant physiology and changing the rhizosphere bacterial community
作者：Bai, Yinshuang;Zhou, Yifan;Huang, Yanna;He, Chuan;Jiang, Wei;Liu, Hua;Zeng, Haijuan;Wang, Jinbin;He, Chuan;Jiang, Wei;Liu, Hua;Zeng, Haijuan;Wang, Jinbin;Bai, Yinshuang;Yue, Tong
关键词：Salt stress; Plant growth -promoting rhizobacteria; Lettuce; Active oxygen scavenging; Osmotic adjustment; Bacterial community
