Genome-wide analysis of circRNA regulation during spleen development of Chinese indigenous breed Meishan pigs
文献类型： 外文期刊
第一作者： Wang, Yifu
作者： Wang, Yifu;Xu, Chao;Bao, Wenbin;Wu, Shenglong;Wu, Zhengchang;Jin, Jian;Wu, Zhengchang;Wu, Zhengchang;Cheng, Jinhua
作者机构：
关键词： Porcine; CircRNAs; Spleen; Development
期刊名称：BMC GENOMICS （ 影响因子：4.4； 五年影响因子：4.7 ）
ISSN： 1471-2164
年卷期： 2023 年 24 卷 1 期
页码：
收录情况： SCI
摘要： BackgroundNumerous circular RNAs (circRNAs) have been recently identified in porcine tissues and cell types. Nevertheless, their significance in porcine spleen development is yet unelucidated. Herein, we reported an extensive overlook of circRNA expression profile during spleen development in Meishan pigs.ResultsOverall, 39,641 circRNAs were identified from 6,914 host genes. Among them, many circRNAs are up- or down-regulated at different time points of pig spleen development. Using WGCNA analysis, we revealed two essential modules for protein-coding genes and circRNAs. Subsequent correlation analysis revealed 67 circRNAs/co-expressed genes that participated in immnue-associated networks. Furthermore, a competing endogenous RNA (ceRNA) network analysis of circRNAs revealed that 12 circRNAs modulated CD226, MBD2, SAMD3, SIT1, SRP14, SYTL3 gene expressions via acting as miRNA sponges. Moreover, the circRNA_21767/miR-202-3p axis regulated SIT1 expression in a ceRNA manner, which is critical for the immune-based regulation of spleen development in Meishan pigs.ConclusionsOverall, our results demonstrated that the circRNAs were differentially expressed during different stages of porcine spleen development, meanwhile the circRNAs interacted with immune-related genes in a ceRNA-based fashion. Moreover, we presented biomedical researchers with RNAseqTools, a user-friendly and powerful software for the visualization of transcriptome profile data.
分类号：
- 相关文献
作者其他论文 更多>>
-
In situ analysis of metallodrugs at the single-cell level based on synchrotron radiation technology
作者：Yao, Qingqiang;Zhang, Chunyu;Yao, Qingqiang;Zhang, Chunyu;Yao, Qingqiang;Zhang, Chunyu;Xu, Chao;Xia, Dongfang;Wang, Yaling;Zhang, Xiangchun
关键词：Metallodrugs; Single-cell analysis; Synchrotron radiation technology; Cell imaging; Metabolism and transformation
-
Effects of Dietary Alfalfa Meal Supplementation on the Growth Performance, Nutrient Apparent Digestibility, Serum Parameters, and Intestinal Microbiota of Raccoon Dogs (Nyctereutes procyonoides)
作者：Chen, Xiaoli;Li, Xiao;Chen, Danyang;Zhao, Weigang;Yuan, Weitao;Xu, Chao;Zhang, Xiuli;Deng, Xuming;Si, Huazhe;Du, Rui;Xu, Chao
关键词：raccoon dog; alfalfa meal; dietary fiber; growth performance; nutrient apparent digestibility; serum parameters; intestinal microbiota
-
Identification of the Effects of 5-Azacytidine on Porcine Circovirus Type 2 Replication in Porcine Kidney Cells
作者：Shan, Yiyi;Wu, Shenglong;Bao, Wenbin;Wu, Zhengchang;Xiao, Qi;He, Kongwang;Xiao, Qi;He, Kongwang;Xiao, Qi;He, Kongwang;Xiao, Qi;He, Kongwang;Wu, Zhengchang
关键词：5-Azacytidine; porcine circovirus type 2; porcine kidney cells
-
Bacterial Community Influences the Effects of Lactobacillus acidophilus on Lipid Metabolism, Immune Response, and Antioxidant Capacity in Dogs
作者：Mao, Aipeng;Nan, Weixiao;Huang, Yao;Mao, Aipeng;Chen, Xiaoli;Zhao, Weigang;Huang, Yao;Xu, Chao;Sun, Yalong;Zhang, Haihua
关键词：Lactobacillus acidophilus; dog; serum indices; bacterial community; correlation analysis
-
Exploration of the protective mechanisms of Icariin against cisplatin-induced renal cell damage in canines
作者：Liu, Jiayi;Xie, Liuwei;Zhai, He;Wang, Dongwei;Wang, Yao;Song, Mingqiang;Li, Xiao;Xu, Chao
关键词：Icariin; cisplatin; MDCK cells; apoptosis of cells; protection effect
-
Quantifying High-Temperature-Induced Injury in Nanfeng Tangerine Plants: Insights from Photosynthetic and Biochemical Mechanisms
作者：Xu, Chao;Wang, Yuting;Yang, Huidong;Tang, Yuqing;Liu, Xincheng;Liu, Buchun;Hu, Xinlong;Hu, Zhongdong;Xu, Chao;Wang, Yuting;Yang, Huidong;Tang, Yuqing;Liu, Buchun;Hu, Xinlong;Hu, Zhongdong;Xu, Chao
关键词：Nanfeng tangerine plants; high-temperature stress; photosynthesis; oxidative stress; high-temperature stress level
-
Different long-term fertilization regimes affect soil protists and their top-down control on bacterial and fungal communities in Mollisols
作者：Hu, Xiaojing;Gu, Haidong;Liu, Junjie;Jin, Jian;Wang, Guanghua;Wei, Dan;Zhou, Baoku;Chen, Xueli;Zhu, Ping;Cui, Xi'an;Wei, Dan;Wang, Guanghua
关键词：Fertilization; Protistan community; Functional group; Inter-kingdom interactions; Mollisols
