Bacterial Community Influences the Effects of Lactobacillus acidophilus on Lipid Metabolism, Immune Response, and Antioxidant Capacity in Dogs

文献类型： 外文期刊

第一作者： Mao, Aipeng

作者： Mao, Aipeng;Nan, Weixiao;Huang, Yao;Mao, Aipeng;Chen, Xiaoli;Zhao, Weigang;Huang, Yao;Xu, Chao;Sun, Yalong;Zhang, Haihua

作者机构：

关键词： Lactobacillus acidophilus; dog; serum indices; bacterial community; correlation analysis

期刊名称：ANIMALS （ 影响因子：3.0； 五年影响因子：3.2 ）

ISSN： 2076-2615

年卷期： 2024 年 14 卷 9 期

页码：

收录情况： SCI

摘要： Simple Summary: In the process of domestication and urbanization, people and small companion animals share, to varying degrees, their dietary style and living environment, and they also encounter similar lifestyle challenges, such as obesity and other diseases. In our study, Lactobacillus acidophilus can improve the body's lipid metabolism and immune and antioxidant capacity by regulating the relative abundance of intestinal bacterial community, which enables companion animals more easily adapt to the lifestyle of lower level of physical activity in the city, thereby improving animal health and well-being. Lactobacillus acidophilus (L. acidophilus), the most prevalent probiotic, has demonstrated the ability to improve the relative abundance of intestinal microorganisms and boost immunity. However, the underlying mechanisms of these effects remain unclear. This study evaluated body weight, nutrient apparent digestibility, serum indices, and bacterial communities in Chinese rural dogs from a L. acidophilus supplementation group (Lactobacillus acidophilus, n = 6) and a control group (CON, n = 6). The results indicated that L. acidophilus had no significant impact on the body weight and apparent nutrient digestibility of Chinese rural dogs. In comparison with the CON group, L. acidophilus significantly reduced the levels of cholesterol (CHO) and increased the levels of IgA, IFN-alpha, and T-AOC. Bacterial diversity indices were significantly reduced in the LAC group compared to the CON groups, and MetaStat analysis demonstrated notable distinctions in 14 bacterial genera between the groups. These bacterial genera exhibited correlations with physiological indices such as CHO, IgA, IFN-alpha, and T-AOC. In conclusion, L. acidophilus can modulate lipid metabolism, immunity, and antioxidant capacity by regulating the relative abundance of specific bacterial communities, which helps dogs to adapt to today's lifestyle.

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