Western equine encephalitis virus virus-like particles from an insect cell-baculovirus system elicit the strong immune responses in mice

文献类型： 外文期刊

第一作者： Ma, JinZhu

作者： Ma, JinZhu;Wang, HuaLei;Zheng, XueXing;Wu, HongXia;Yang, SongTao;Xia, XianZhu;Ma, JinZhu

作者机构：

关键词： baculoviruses; cytokine; neutralizing antibodies; Sf9 cells; virus-like particles; western equine encephalitis virus

期刊名称：BIOTECHNOLOGY JOURNAL （ 影响因子：4.677； 五年影响因子：4.596 ）

ISSN： 1860-6768

年卷期： 2021 年 16 卷 8 期

页码：

收录情况： SCI

摘要： Western equine encephalitis virus (WEEV) causes lethal encephalitis in humans and equines, and it poses a serious public health threat in many countries. Therefore, the development of an efficient vaccine remains an important challenge for the prevention of WEEV infection. This study presents the first description of WEEV virus-like particles (VLPs) generated from insect cells using recombinant baculoviruses. WEEV VLPs with 206 adjuvant could trigger a strong cellular immune response; increase the levels of IL-2, IL-4 and IFN-gamma; and induce a high level of neutralizing antibodies against WEEV in mice. These data showed that the insect cell-baculovirus system is suitable for the production of WEEV VLPs and that these VLPs could elicit the strong immunogenicity in mice. These results suggest a new, nonreplicating, and effective vaccine candidate against WEEV infection.

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