Structural Elucidation of a Polysaccharide from Flammulina velutipes and Its Lipid-Lowering and Immunomodulation Activities

文献类型： 外文期刊

第一作者： Jia, Wei

作者： Jia, Wei;Wang, Wenhan;Yu, Dongsheng;Zhang, Jingsong;Zhang, Henan;Jia, Wei;Wang, Wenhan;Yu, Dongsheng;Zhang, Jingsong;Zhang, Henan;Yu, Yangchao;Feng, Zhan;Li, Hewen

作者机构：

关键词： Flammulina velutipes; polysaccharides; three-phase partitioning; structural characteristics; lipid-lowering activity; immunoregulatory activity

期刊名称：POLYMERS （ 影响因子：5.0； 五年影响因子：5.0 ）

ISSN：

年卷期： 2024 年 16 卷 5 期

页码：

收录情况： SCI

摘要： FVPT1, a novel heteropolysaccharide, was purified from the fruiting body of Flammulina velutipes using magnetic-field-assisted three-phase partitioning and gel permeation chromatography. The structure was characterized using monosaccharide composition and methylation analysis, infrared spectroscopy and nuclear magnetic resonance (NMR). The FVPT1 (similar to 1.64 x 10(4) Da) was composed of L-fucose, D-galactose, D-glucose and D-mannose at a molar ratio of 1.0:3.5:1.0:1.4. The polysaccharide repeating unit of FVPT1 was established with methylation analyses and NMR spectroscopy. Moreover, a zebrafish larva hyperlipidemia model test demonstrated that FVPT1 can show appreciable lipid-lowering effects. In addition, the FVPT1 exhibited remarkable immunoregulatory activity by increasing nitric oxide, interleukin (IL)-1 beta and IL-1 secretion in macrophages. Therefore, these results suggest that FVPT1 has the potential to be developed into a new immune or hypolipidemic health product.

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