Removal of antibiotic resistance genes and inactivation of antibiotic-resistant bacteria by oxidative treatments

文献类型： 外文期刊

第一作者： Zhao, Xiaoyu

作者： Zhao, Xiaoyu;Su, Haochang;Xu, Wujie;Hu, Xiaojuan;Xu, Yu;Wen, Guoliang;Cao, Yucheng;Zhao, Xiaoyu;Su, Haochang;Xu, Wujie;Hu, Xiaojuan;Xu, Yu;Wen, Guoliang;Cao, Yucheng

作者机构：

关键词： Antibiotic resistance genes; Antibiotic-resistant bacteria; Chlorine; Bromine; Potassium permanganate

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：7.963； 五年影响因子：7.842 ）

ISSN： 0048-9697

年卷期： 2021 年 778 卷

页码：

收录情况： SCI

摘要： The persistence of antibiotics in the environment because of human activities, such as seafood cultivation, has attracted great attention as they can give rise to antibiotic resistance genes (ARGs) and antibiotic-resistant bacteria (ARB). In this study, we explored the inactivation and removal efficiencies of Escherichia coli SR1 and sul1 (plasmid-encoded ARGs), respectively, in their extracellular and intracellular forms (eARGs and iARGs) by three commonly used fishery oxidants, namely chlorine, bromine, and potassium permanganate (KMnO4), at the practical effective concentration range (0.5, 5, and 15 mg/L). Kinetics data were obtained using laboratory phosphate-buffered saline (PBS). Following the same fishery oxidation methods, the determined kinetics models were tested by studying the SR1 and sul1 disinfection efficiencies in (sterilized) pond water matrix. At concentra-tions of 5 and 15 mg/L, all three oxidants achieved sufficient cumulative integrated exposure (CT values) to completely inactivate SR1 and efficiently remove sul1 (up to 4.0-log). The oxidation methods were then applied to an unsterilized pond water matrix in order to study and evaluate the indigenous ARB and ARGs disinfection efficiencies in aquaculture, which reached 1.4-log and 1.0-log during treatment with fishery oxidants used in pond preparation at high concentrations before stocking (5-15 mg/L), respectively. A high chlorine concentra-tion (15 mg/L) could efficiently remove ARGs (or iARGs) from pond water, and the iARG removal efficiency was higher than that of eARGs in pond water. The method and results of this study could aid in guiding future research and practical disinfection to control the spread of ARGs and ARB in aquaculture. (C) 2021 Elsevier B.V. All rights reserved.

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