Role of white adipose tissue browning in cold seasonal acclimation in grazing Mongolian sheep (Ovis aries)

文献类型： 外文期刊

第一作者： Zhang, Yan-Mei

作者： Zhang, Yan-Mei;Erdene, Khas;Zhao, Ya-Bo;Ao, Chang-Jin;Li, Chang-Qing;Wang, Li;Tian, Feng;Jin, Hai

作者机构：

关键词： Seasonal acclimation; Mongolian sheep ( Ovis aries ); Cold tolerant; White adipose tissue; Uncoupling protein 1; Browning

期刊名称：JOURNAL OF THERMAL BIOLOGY （ 影响因子：3.189； 五年影响因子：3.342 ）

ISSN： 0306-4565

年卷期： 2022 年 109 卷

页码：

收录情况： SCI

摘要： Mongolian sheep are characteristically cold-tolerant and thus can survive well and maintain genetic stability in the extremely cold environment of the Mongolian Plateau. However, the adaptive mechanism of Mongolian sheep during the cold season in the plateau environment remains unknown. Browning of white adipose tissues (WAT) can trigger nonshivering thermogenesis as a potential strategy to promote an animal's tolerance to cold environments. Thus, a comparative analysis of the genes and proteins of uncoupling protein 1 (UCP1)-dependent and UCP1-independent browning pathways, mitochondrial biogenesis, lipogenic and lipolytic processes of WAT from grazing Mongolian sheep in the cold and warm seasons was conducted. We found seasonal browning of both retroperitoneal WAT and perirenal WAT, and the signalling of the process was mainly transduced by the UCP1-dependent pathway, primarily reflected in the upregulated gene levels of UCP1 and peroxisome prolif-erative activated receptor gamma coactivator 1 alpha (PGC-1 alpha). In addition, the mean adipocyte diameter and mRNA expression of lipogenic genes in both interscapular WAT and subcutaneous WAT were significantly elevated during the cold season. The findings of this study demonstrate that grazing Mongolian sheep could depend on seasonal browning of both retroperitoneal WAT and perirenal WAT together with the expansion of both interscapular WAT and subcutaneous WAT to acclimate to cold environments of the Mongolian Plateau.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序