文献类型： 外文期刊
第一作者： Fan, Lusheng
作者： Fan, Lusheng;Fan, Lusheng;Gao, Bin;Xu, Ye;Flynn, Nora;Le, Brandon;Yang, Zhenbiao;Chen, Xuemei;You, Chenjiang;You, Chenjiang;Li, Shaofang;Achkar, Natalia;Manavella, Pablo A.
作者机构：
关键词： microRNA; HYL1; AAR2; pri-miRNA
期刊名称：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA （ 影响因子：11.1； 五年影响因子：12.0 ）
ISSN： 0027-8424
年卷期： 2022 年 119 卷 41 期
页码：
收录情况： SCI
摘要： MicroRNAs (miRNAs) play an essential role in plant growth and development, and as such, their biogenesis is fine-tuned via regulation of the core microprocessor components. Here, we report that Arabidopsis AAR2, a homolog of a U5 snRNP assembly factor in yeast and humans, not only acts in splicing but also promotes miRNA biogenesis. AAR2 interacts with the microprocessor component hyponastic leaves 1 (HYL1) in the cytoplasm, nucleus, and dicing bodies. In aar2 mutants, abundance of nonphosphorylated HYL1, the active form of HYL1, and the number of HYL1-labeled dicing bodies are reduced. Primary miRNA (pri-miRNA) accumulation is compromised despite normal promoter activities of MIR genes in aar2 mutants. RNA decay assays show that the aar2-1 mutation leads to faster degradation of pri-miRNAs in a HYL1-dependent manner, which reveals a previously unknown and negative role of HYL1 in miRNA biogenesis. Taken together, our findings reveal a dual role of AAR2 in miRNA biogenesis and premessenger RNA splicing.
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