Long-Term Exposure to Phenanthrene Induced Gene Expressions and Enzyme Activities of Cyprinus carpio below the Safe Concentration

文献类型： 外文期刊

第一作者： Kang, Xin

作者： Kang, Xin;Li, Dongpeng;Zhao, Xiaoxiang;Lv, Yanfeng;Song, Xinshan;Cao, Xin;Chen, Xi;Liu, Xiangyu;Chen, Chengrong

作者机构：

关键词： Cyprinus carpio; phenanthrene ecotoxicology; cytochrome P4501A; 7-ethoxylesorufin O-deethylase; glutathione S-transferase

期刊名称：INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH （ 影响因子：4.614； 五年影响因子：4.798 ）

ISSN：

年卷期： 2022 年 19 卷 4 期

页码：

收录情况： SCI

摘要： Phenanthrene (PHE) is a typical compound biomagnified in the food chain which endangers human health and generally accumulates from marine life. It has been listed as one of the 16 priority PAHs evaluated in toxicology. In order to evaluate the changes of CYP1A GST mRNA expression and EROD GST enzyme activity in carp exposed to lower than safe concentrations of PHE. Long-term exposure of carp to PHE at lower than safe concentrations for up to 25 days. The mRNA expression level and cytochrome P450 (CYP1A/EROD (7-Ethoxylesorufin O-deethylase)) and glutathione S-transferase (GST) activity were measured in carp liver and brain tissue. The results showed that PHE stress induced low-concentration induction and high-concentration inhibition of CYP1A expression and EROD enzyme activity in the liver and brain of carp. In both two organs, GST enzyme activity was also induced. However, the expression of GST mRNA was first induced and then inhibited, after the 15th day. These results indicate that long-term exposure to PHE at lower than safe concentrations still poses a potential threat to carp's oxidase system and gene expression.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序