Immunomodulatory effects of the polysaccharide from Sinonovacula constricta on RAW264.7 macrophage cells
文献类型： 外文期刊
第一作者： Liu, Zhidong
作者： Liu, Zhidong;Liu, Zhifang;Lin, Na;Jiang, Mei;Li, Laihao;Zhang, Junjie;Zhao, Qiancheng;Zhong, Wenzhu
作者机构：
关键词： immunomodulatory activity; macrophage; polysaccharide; Sinonovacula constricta
期刊名称：FOOD SCIENCE & NUTRITION （ 影响因子：3.553； 五年影响因子：3.634 ）
ISSN： 2048-7177
年卷期： 2022 年 10 卷 4 期
页码：
收录情况： SCI
摘要： This study aimed to evaluate the immunomodulatory effect of the polysaccharide from Sinonovacula constricta (SCP-1-1) in RAW264.7 cells, SCP-1-1 with a molecular weight of 440.0 kDa consisted of glucose and mannose. The immunomodulatory assay results showed that SCP-1-1 could significantly enhance phagocytic ability, NO production, and some cytokines (TNF-alpha, IL-6, and IL-1 beta) secretion of RAW264.7 cell in a dose-dependent manner. Western blot analysis results demonstrated that SCP-1-1 could regulate the expression levels of the key proteins in the signaling pathways of RAW264.7 cell and might associated with NF-kappa beta and P13K signaling pathway. These findings could contribute to elucidate the immunomodulatory activities of the polysaccharide from Sinonovacula constricta.
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