Milk Extracellular Vesicles: Natural Nanoparticles for Enhancing Oral Drug Delivery against Bacterial Infections

文献类型： 外文期刊

第一作者： Dai, Cunchun

作者： Dai, Cunchun;Xu, Qingjun;Li, Lin;Qu, Shaoqi;Xu, Qingjun;Qu, Shaoqi;Liu, Ying

作者机构：

关键词： extracellular vesicles; milk; oral delivery; bacterial infections

期刊名称：ACS BIOMATERIALS SCIENCE & ENGINEERING （ 影响因子：5.8； 五年影响因子：5.6 ）

ISSN： 2373-9878

年卷期： 2024 年 10 卷 4 期

页码：

收录情况： SCI

摘要： Oral drug delivery is typically preferred as a therapeutic intervention due to the complexities and expenses associated with intravenous administration. However, some drugs are poorly absorbed orally, requiring intravenous administration to bypass the gastrointestinal tract and deliver the drug directly into the bloodstream. Thus, there is an urgent need to develop novel drug delivery platforms to overcome the challenges of oral drug delivery with low solubility, low permeability, oral degradation, and low bioavailability. Advances in extracellular vesicles (EVs) as natural carriers have provided emerging approaches to improve potential therapeutic applications. Milk not only contains traditional nutrients but is also rich in EVs. In this Review, we focus mainly on the purification of milk EVs (mEVs), their safety, and the advantages of mEV-based drug carriers in combatting intestinal infections. Additionally, we summarize several advantages of mEVs over conventional synthetic carriers, such as low immunogenicity, high biocompatibility, and the ability to transfer bioactive molecules between cells. Considering the unmet gaps of mEVs in clinical translation, it is essential to review the cargo loading into mEVs and future perspectives for their use as natural drug carriers for oral delivery. This overview of mEV-based drug carriers for oral delivery sheds light on alternative approaches to treat clinical infections associated with intestinal pathogens and the development of novel oral delivery systems.

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