A natural variation of flavone synthase II gene enhances flavone accumulation and confers drought adaptation in chrysanthemum

文献类型： 外文期刊

第一作者： Luo, Jiayi

作者： Luo, Jiayi;Han, Mingzheng;Song, Zhenzhen;Zhang, Haixia;Zhao, Yafei;Ma, Chao;Luo, Chang;Huang, Conglin;Wang, Qinrui;Gao, Qiang;Lin, Tao

作者机构：

关键词： Chrysanthemum; drought; flavone; FNSII; GWAS

期刊名称：NEW PHYTOLOGIST （ 影响因子：8.1； 五年影响因子：10.3 ）

ISSN： 0028-646X

年卷期： 2025 年 247 卷 3 期

页码：

收录情况： SCI

摘要： Flavones, a key group of flavonoids, play a significant role in plant adaptation to ecological niches and are valuable medicinal resources. However, the genetic basis underlying their contribution to ecological adaptation remains largely unknown. Here, using metabolite-based genome-wide association study, we report that the natural variation of flavone contents in Chrysanthemum indicum, a wild chrysanthemum and medicinal herb, is mainly determined by a recently duplicated flavone synthase II gene CiFNSII-1.2. Enzymatic assays and molecular dynamics simulations reveal that the key amino acid residues 246th and 261th confer the higher enzymatic activity of CiFNSII-1.2 compared with its ancestral form. These residues act as critical modulators, regulating the flexibility of the external entrance and contributing to the enzyme's improved functionality. Transgenic evaluation demonstrate that CiFNSII-1.2 contributes to flavone accumulation and drought adaptation. Our findings provide insights into the biochemical and evolutionary role of flavones in facilitating adaptation to drought-prone habitats in chrysanthemum.

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