文献类型： 外文期刊
第一作者： Hong, Weiling
作者： Hong, Weiling;Sheng, Yingkun;Wei, Hewen;Lu, Shengmin
作者机构：
关键词： Vascular calcification; Alternative splicing; Biomarkers
期刊名称：CELLULAR SIGNALLING （ 影响因子：3.7； 五年影响因子：4.2 ）
ISSN： 0898-6568
年卷期： 2025 年 127 卷
页码：
收录情况： SCI
摘要： Vascular calcification(VC) significantly increases the risk of cardiovascular events, leading to thickening of the myocardium and arteries, coronary heart disease, heart failure, and potentially triggering myocardial infarction and sudden cardiac death. Although VC is a reversible process, there are currently no methods or medications in clinical practice that can completely reverse or cure it. The current treatment strategies primarily focus on slowing the progression of VC and exploring new diagnostic and therapeutic approaches, making the identification of early diagnostic markers for VC particularly important. Alternative splicing(AS)has extensive potential in clinical applications as a biomarker, including in disease diagnosis and therapeutic targeting. This article provides an overview of the roles played by different isoforms of biomarkers in VC, with the aim of offering insights for early diagnosis and disease monitoring of VC.
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