Dendrobium officinale leaf polysaccharide has a dual effect of alleviating the syndromes of immunosuppressed mice and modulating immune system of normal mice

文献类型： 外文期刊

第一作者： Li, Jingrui

作者： Li, Jingrui;Tao, Wenyang;Zhou, Wanyi;Xing, Jianrong;Luo, Mengfan;Lu, Shengmin;Yang, Ying

作者机构：

关键词： Dendrobium officinale leaf; Polysaccharide; Immune system; Gut microbiota; Cyclophosphamide

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.6； 五年影响因子：5.3 ）

ISSN： 1756-4646

年卷期： 2024 年 113 卷

页码：

收录情况： SCI

摘要： This study aimed to explore the immunomodulatory activity of Dendrobium officinale leaf polysaccharide (DOLP) in both immunosuppressed and normal mice. The data showed that DOLP significantly reversed thymic and splenic damage in immunosuppressed mice, regulated their peripheral blood cells (PLT, etc.), immune -related cytokines (TNF-alpha, INF-gamma and IL -6) and immunoglobulins (IgA, IgG and IgM) production, and increased the relative abundance of beneficial bacteria (Lactobacillus and Bifidobacterium, etc.) while decreased that of pathogenic bacteria (Desulfovibrio, etc.). In normal mice, DOLP significantly increased immune -related cytokines (TNF-alpha, INF-gamma, and IL -6), gut microbiota diversity, and the relative abundance of beneficial bacteria (unclassi- fied_f_Lachnospiraceae_NK4A136_group, etc.). The results indicated that DOLP could exert immune modulating effects both on immunosuppressed mice and normal mice by modulating immune parameters and gut microbiota. These findings provide new insights into the immune -modulating effects of DOLP and a solid basis for the thorough utilization of DOLP.

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