A Trim-RBD-GEM vaccine candidate protects mice from SARS-CoV-2

文献类型： 外文期刊

第一作者： Wang, Jianzhong

作者： Wang, Jianzhong;Xia, Xianzhu;Gao, Yuwei;Shi, Zhuangzhuang;Li, Entao;Zhu, Menghan;Li, Dongxu;Liu, Xiawei;Sun, Yue;Feng, Na;Wang, Tiecheng;Xia, Xianzhu;Sun, Weiyang;Gao, Yuwei;Li, Entao;Zhu, Menghan;Liu, Xiawei;Li, Dongxu;Sun, Yue;Gao, Yuwei

作者机构：

关键词： SARS-CoV-2 pandemic; Bacterium -like particle; AddaVax adjuvant; Al(OH) 3 adjuvant

期刊名称：VIROLOGY （ 影响因子：3.7； 五年影响因子：3.2 ）

ISSN： 0042-6822

年卷期： 2023 年 585 卷

页码：

收录情况： SCI

摘要： The SARS-CoV-2 pandemic has continued for about three years since emerging in late December 2019, resulting in millions of deaths. Therefore, there is an urgent need to develop a safe and effective vaccine to control SARSCoV-2. In this study, we developed a bacterium-like particle vaccine that displays the SARS-CoV-2 receptor binding domain (RBD) (named Trim-RBD-GEM) using the GEM-PA system. We evaluated the immunogenicity and protective efficacy of the Trim-RBD-GEM vaccine with the oil-in-water adjuvant AddaVax in C57BL/6 N mice intramuscularly. We found that Trim-RBD-GEM & AddaVax induced high levels of humoral immunity in C57BL/6 N mice. Additionally, the lung virus loads in the immunized group were significantly decreased compared to the adjuvant control and mock groups. Therefore, this vaccine provides protection against lethal infection in a C57BL/6 N mouse model. Our Trim-RBD-GEM & AddaVax vaccine is potentially a promising, rapid, and safe subunit vaccine for preventing and controlling SARS-CoV-2.

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