Unlocking the mysteries of milk oligosaccharides: Structure, metabolism, and function

文献类型： 外文期刊

第一作者： Yao, Qianqian

作者： Yao, Qianqian;Gao, Yanan;Zheng, Nan;Wang, Jiaqi;Yao, Qianqian;Delcenserie, Veronique;Wang, Jiaqi

作者机构：

关键词： Milk oligosaccharides (MOs); Human milk; Animal milk; Beneficial function; Application

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：11.2； 五年影响因子：10.2 ）

ISSN： 0144-8617

年卷期： 2024 年 332 卷

页码：

收录情况： SCI

摘要： Milk oligosaccharides (MOs), complex carbohydrates prevalent in human breast milk, play a vital role in infant nutrition. Serving as prebiotics, they inhibit pathogen adherence, modulate the immune system, and support newborn brain development. Notably, MOs demonstrate significant variations in concentration and composition, both across different species and within the same species. These characteristics of MOs lead to several compelling questions: (i) What distinct beneficial functions do MOs offer and how do the functions vary along with their structural differences? (ii) In what ways do MOs in human milk differ from those in other mammals, and what factors drive these unique profiles? (iii) What are the emerging applications of MOs, particularly in the context of their incorporation into infant formula? This review delves into the structural characteristics, quantification methods, and species -specific concentration differences of MOs. It highlights the critical role of human MOs in infant growth and their potential applications, providing substantial evidence to enhance infant health and development.

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