Integrated transcriptomics and metabolomics reveal the toxic mechanisms of mercury exposure to an endangered species Tachypleus tridentatus

文献类型： 外文期刊

第一作者： Xie, Mujiao

作者： Xie, Mujiao;Bao, Yuyuan;Xie, Xiaoyong;Ying, Ziwei;Ye, Guoling;Li, Chunhou;Guo, Qingyang;Zhang, Wanling;Luo, Zimeng;Xie, Mujiao;Bao, Yuyuan;Xie, Xiaoyong;Ying, Ziwei;Ye, Guoling;Guo, Qingyang;Zhang, Wanling;Luo, Zimeng;Xie, Xiaoyong;Ye, Guoling;Xie, Xiaoyong

作者机构：

关键词： Endangered species; Tachypleus tridentatus; Mercury pollution; Omics; Toxic mechanisms

期刊名称：ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY （ 影响因子：4.3； 五年影响因子：4.8 ）

ISSN： 1382-6689

年卷期： 2024 年 105 卷

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收录情况： SCI

摘要： Mercury (Hg) pollution is threatening the health of endangered Tachypleus tridentatus whereas the toxic mechanism is still unclear. This study combined transcriptomic and metabolomics technology to reveal the toxic mechanisms of mercury (Hg 2+, 0.025 mg/L) exposing to T. tridentatus larvae for 15 days. Mercury induced cellular toxicity and cardiovascular dysfunction by dysregulating the genes related to endocrine system, such as polyubiquitin-A, cathepsin B, atrial natriuretic peptide, etc. Mercury induced lipid metabolic disorder with the abnormal increase of lysoPC, leukotriene D4, and prostaglandin E2. Cytochrome P450 pathway was activated to produce anti-inflammatory substances to reconstruct the homeostasis. Mercury also inhibited arginine generation, which may affect the development of T. tridentatus by disrupting the crucial signaling pathway. The mercury methylation caused enhancement of S-adenosylmethionine to meet the need of methyl donor. The mechanisms described in present study provide new insight into the risk assessment of mercury exposure to T. tridentatus.

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