A novel antimicrobial peptide CpAMP identified from Chinese horseshoe crab, Tachypleus tridentatus

文献类型： 外文期刊

第一作者： Wang, Weifeng

作者： Wang, Weifeng;Wei, Sisi;Guo, Baoying;Wang, Weifeng;Liu, Hong;Wang, Huanling;Xie, Xiaoyong

作者机构：

关键词： Antimicrobial peptides; Tachypleus tridentatus; Broad-spectrum activity

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：3.9； 五年影响因子：4.2 ）

ISSN： 1050-4648

年卷期： 2025 年 156 卷

页码：

收录情况： SCI

摘要： Antibacterial peptide (AMP) is a crucial component of the innate immune system in most organism, play an important role in host defense processes. Many of these peptides have broad antimicrobial activity against Gramnegative, -positive bacteria and fungi. In the present study, a novel AMP named CpAMP was identified using transcriptome analysis in Chinese horseshoe crab. The preprotein of CpAMP consists of a signal peptide (21 aa) and a mature peptide (47 aa) enriched by cysteine. And the putative mature peptide CpAMP was 4.95 kDa with a theoretical isoelectric point (pI) of 8.73. The mature CpAMP showed alpha-helix and irregularly curled structure in the cys-stabilized region. CpAMP exhibited a broad spectrum of antimicrobial activity against Gram-negative, -positive bacteria and antibiotic-resistant strains. In addition, CpAMP can significantly increase the survival rate of zebrafish infected with bacteria. Due to its broad-spectrum antibacterial activity and the sensitivity of drug-resistant strains, CpAMP could be used as a new type of drug for inhibition of pathogenic microorganisms or as an immune enhancer in animals.

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