Nutrition and flavor analysis of Spirulina through co-fermentation with Lactobacillus acidophilus and Kluyveromyces marxianus and its effect on attenuating metabolic associated fatty liver disease

文献类型： 外文期刊

第一作者： Yu, Jinhui

作者： Yu, Jinhui;Liu, Chao;Liu, Yuanyuan;Ma, Deyuan;Chen, Gao;Han, Fuwen;You, Shengbo;Bi, Yuping;Wu, Yingjie;Yu, Jinhui;Ma, Deyuan;Chen, Gao;You, Shengbo;Bi, Yuping;Liu, Chao;Wang, Mingjie;Wang, Mingjie;Liu, Yuanyuan;Ran, Liyuan;Yu, Zichao;Wu, Yingjie

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关键词： Spirulina; Lactobacillus acidophilus; Kluyveromyces marxianus; Co -fermentation; MAFLD

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.6； 五年影响因子：5.3 ）

ISSN： 1756-4646

年卷期： 2024 年 116 卷

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收录情况： SCI

摘要： Spirulina is widely known as the "Super Nutritious Food of the Future" due to its exceptional nutritional properties. In this article, we investigated the effects of fermentation using a combination of Lactobacillus acidophilus KDB-03 and Kluyveromyces marxianus GDMCC 2.119 on Spirulina. Fermentation significantly increased the total flavonoid and phenol levels in Spirulina, and enhanced the 2,2-diphenyl-1-picrylhydrazyl free radical scavenging capacity and ferric-reducing antioxidant power. Untargeted ultra-performance liquid chromatography-electrospray tandem mass spectrometry-based metabolomics and gas chromatography-ion mobility spectrometry analysis revealed alterations in the metabolites and flavor components of fermented Spirulina (FS). Furthermore, a mice experiment demonstrated that FS could effectively alleviate metabolismassociated fatty liver disease (MAFLD) by regulating liver metabolism, intestinal flora, and facilitating communication between the liver and gut. These findings suggest that fermentation could be a innovative approach to enhance the diversity of Spirulina products, and potentially be used as a strategy for the prevention and treatment of MAFLD.

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