Methylotrophic yeasts for chemicals production using methanol as substrate: Current status, challenges, and strategies

文献类型： 外文期刊

第一作者： Duan, Xiyu

作者： Duan, Xiyu;Wang, Zhi;Wang, Chong;Yang, Xiaona;Liu, Huhu;Lu, Xiangyang;Tian, Yun;Li, Changzhu;Li, Peiwang;Tian, Yun;Wang, Chong;Yang, Xiaona;Liu, Huhu;Lu, Xiangyang;Li, Changzhu;Li, Peiwang;Tian, Yun;Tian, Yun

作者机构：

关键词： Methylotrophic yeasts; Methanol; C1 substrate; Metabolic engineering; Green biomanufacturing

期刊名称：BIORESOURCE TECHNOLOGY （ 影响因子：9.0； 五年影响因子：9.5 ）

ISSN： 0960-8524

年卷期： 2025 年 434 卷

页码：

收录情况： SCI

摘要： Methanol, an inexpensive and renewable feedstock, has garnered significant attention in the green biomanufacturing industry. The bioconversion of methanol to chemicals offers a promising way to combat the food crisis and mitigate climate change. Methylotrophic yeasts, which are promising candidates, have a natural compartmentalized ability to utilize methanol, effectively reducing the toxic effects of methanol metabolism on cells. This review comprehensively summarizes the recent progress in the bioconversion of methanol for chemical production using methylotrophic yeasts. Furthermore, a series of feasible strategies are proposed to address the challenges of low utilization of methanol, cytotoxicity of methanol and its derivative formaldehyde, and oxidative stress. Finally, the future development directions of methylotrophic yeasts are outlined.

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