Autoinducer-2 relieves soil stress-induced dormancy of Bacillus velezensis by modulating sporulation signaling

文献类型： 外文期刊

第一作者： Xiong, Qin

作者： Xiong, Qin;Xiong, Qin;Shu, Xia;Sun, Xiting;Zhang, Ruifu;Liu, Yunpeng;Xiong, Qin;Zhang, Huihui;Feng, Haichao;Xu, Zhihui;Zhang, Ruifu;Kovacs, Akos T.;Kovacs, Akos T.

作者机构：

期刊名称：NPJ BIOFILMS AND MICROBIOMES （ 影响因子：9.2； 五年影响因子：9.9 ）

ISSN：

年卷期： 2024 年 10 卷 1 期

页码：

收录情况： SCI

摘要： The collective behavior of bacteria is regulated by quorum sensing (QS). Autoinducer-2 (AI-2) is a common QS signal that regulates the behavior of both Gram-positive and Gram-negative bacteria. Despite the plethora of processes described to be influenced by AI-2 in diverse Gram-negative bacteria, the AI-2-regulated processes in Bacilli are relatively unexplored. Here, we describe a novel function for AI-2 in Bacillus velezensis SQR9 related to the sporulation. AI-2 inhibited the initiation of sporulation through the phosphatase RapC and the DNA binding regulator ComA. Using biochemistry experiments, we demonstrated that AI-2 interacts with RapC to stimulate its binding to ComA, which leads to an inactive ComA and subsequently a sporulation inhibition. The AI-2 molecule could be shared across species for inhibiting Bacillus sporulation and it also plays the same role in different soil conditions. Our study revealed a novel function and regulatory mechanism of AI-2 in inhibiting sporulation in Bacilli.

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