Insecticides and cadmium impair programmed appendage regeneration in Pardosa pseudoannulata: Mechanisms and regulatory dysfunction

文献类型： 外文期刊

第一作者： Zhang, Huihui

作者： Zhang, Huihui;Liu, Zewen;Chen, Yunru;Wang, Jingting;Tao, Tianpeng;Yang, Zhiming;Yu, Na;Liu, Zewen

作者机构：

关键词： Appendage regeneration; Insecticides; Heavy metal; Pardosa pseudoannulata

期刊名称：ENVIRONMENTAL POLLUTION （ 影响因子：7.3； 五年影响因子：8.1 ）

ISSN： 0269-7491

年卷期： 2025 年 384 卷

页码：

收录情况： SCI

摘要： Biological control by natural enemies is critical for sustainable pest management, yet chemical pesticides threaten the efficacy from natural enemies by diminishing their populations and reduce control effectiveness. The spider Pardosa pseudoannulata, a key natural enemy of insect pests, relies on precise appendage regeneration for survival and predation on insects. Early-stage regeneration is governed by the PKA/CREB-mediated melanization pathway, influencing development and initial melanization of regenerated appendages. Here, we reveal that subsequent melanization stages are regulated sequentially by MAPK (mitogen-activated protein kinase) and Wnt (wingless-related integration site) signaling in turn. Low concentrations of insecticides (chlorpyrifos, buprofezin) and heavy metal cadmium caused no direct mortality but severely disrupted regeneration. These chemical stressors dysregulated genes across PKA/CREB, MAPK, and Wnt pathways, impairing development and melanization of regenerated appendages. Our findings highlight how sublethal chemical exposure compromises spider fitness, undermining biological control. This study exposes hidden risks of agrochemicals and heavy metals to arthropod regeneration. It also advances understanding of conserved melanogenesis disruption mechanisms shared across taxa.

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