Epidermal growth factor receptor promotes infectious spleen and kidney necrosis virus invasion via PI3K-Akt signaling pathway

文献类型： 外文期刊

第一作者： Niu, Yinjie

作者： Niu, Yinjie;Fu, Xiaozhe;Lin, Qiang;Liang, Hongru;Luo, Xia;Zuo, Shaozhi;Liu, Lihui;Li, Ningqiu

作者机构：

关键词： epidermal growth factor receptor; infectious spleen and kidney necrosis virus; PI3K; Akt signaling pathway; viral invasion

期刊名称：JOURNAL OF GENERAL VIROLOGY （ 影响因子：3.8； 五年影响因子：3.8 ）

ISSN： 0022-1317

年卷期： 2023 年 104 卷 8 期

页码：

收录情况： SCI

摘要： Infectious spleen and kidney necrosis virus disease (ISKNVD) caused significant economic losses to the fishery industry. Epidermal growth factor receptor (EGFR), phosphatidylinositide 3- kinase (PI3K) played an important role in ISKNV invasion. However, the molecular regulatory mechanisms among EGFR, PI3K- Akt, and ISKNV invasion are not clear. In this study, ISKNV infection rapidly induced EGFR activation. While, EGFR activation promoted virus entry, but EGFR inhibitors and specific RNA (siRNA) decreased virus invasion. The PI3K- Akt as downstream signalling of EGFR was activated upon ISKNV infection. Consistent with the trends of EGFR, Akt activation increased ISKNV entry into cells, Akt inhibition by specific inhibitor or siRNA decreased ISKNV invasion. Akt silencing combination with EGFR activation showed that EGFR activation regulation ISKNV invasion is required for activation of the Akt signalling pathway. Those data demonstrated that ISKNV- induced EGFR activation positively regulated virus invasion by PI3K- Akt pathway and provided a better understanding of the mechanism of EGFR- PI3K- Akt involved in ISKNV invasion.

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