Blood brain barrier permeability and immune function of brain in rainbow trout responding to IHNV infection

文献类型： 外文期刊

第一作者： Sun, Ru-Han

作者： Sun, Ru-Han;Chen, Kai-Wei;Wang, Qin;Huang, Zhen-Yu;Wang, Bing-Chao;Ji, Wei;Shi, Ze-Chao

作者机构：

关键词： Central nervous system; Blood-brain barrier; Immune; Infectious hematopoietic necrosis virus

期刊名称：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY （ 影响因子：3.605； 五年影响因子：3.833 ）

ISSN： 0145-305X

年卷期： 2022 年 135 卷

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收录情况： SCI

摘要： Viral infection of the central nervous system (CNS) is often associated with blood-brain barrier (BBB) disruption. Mammals have developed complicated and efficient immune strategies to protect the BBB. However, the immune defense of brain and BBB permeability changes are not well-understood in teleost during virus invading. In this study, we constructed an infectious hematopoietic necrosis virus (IHNV) immersion infected rainbow trout model. After IHNV infection, pathological changes occurred in the brain, and MPO and ROS activities were significantly increased. In addition, the expression levels of BBB permeability-related genes were also changed. Transcriptome analysis showed that immune-related genes and signaling pathways in the brain were activated after IHNV infection. These results showed that the permeability of BBB increased significantly after IHNV infection, thus activating immune related factors and cells to enter the CNS through blood circulation to resist pathogenic infection.

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