Toxicological effects of Honokiol on zebrafish and its underlying mechanism

文献类型： 外文期刊

第一作者： Lin, Jue

作者： Lin, Jue;Deng, Yongqiang;Liu, Hongli;Huang, Xiaoli

作者机构：

关键词： gill; Honokiol; liver; oxidative stress; toxicology

期刊名称：JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY （ 影响因子：3.2； 五年影响因子：3.3 ）

ISSN： 1095-6670

年卷期： 2024 年 38 卷 8 期

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收录情况： SCI

摘要： The compound Honokiol, derived from the bark of Magnolia officinalis, possesses the ability to induce apoptosis and inhibit cellular damage caused by reactive oxygen species. The objective of this study was to investigate the toxicological and histopathological effects of Honokiol on zebrafish (Danio rerio) through conducting a semistatic acute toxicity test involving immersion in an Honokiol-containing solution. The results showed that the toxic effects of Honokiol on zebrafish were primarily manifested in the liver and gills. When exposed to 0.6 mg/L of Honokiol, it could lead to liver hemorrhage as well as swelling and necrosis of gill tissues, and high concentrations of Honokiol could trigger inflammatory responses. Additionally, research found that Honokiol could induce apoptosis in liver and gill tissues through the P53 pathway and possessed the ability to enhance antioxidation. The present findings significantly contribute to a more profound understanding of the toxic impact of Honokiol and its underlying mechanism, thereby providing a valuable reference for the future safe utilization of Honokiol and related pharmaceutical advancements. Honokiol exhibits toxicity in zebrafish gills and liver, causing hemorrhage, swelling, and necrosis at elevated concentrations. It induces apoptosis in hepatic and gill cells via P53 activation. While possessing antioxidant properties that enhance enzyme function, excessive honokiol may induce inflammation and cell death.image

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