Pathogenic Characterization of a Porcine Circovirus Type 3 Isolate from Heilongjiang, China

文献类型： 外文期刊

第一作者： Wang, Menghang

作者： Wang, Menghang;Wu, Jianan;Meng, Fandan;Tang, Yandong;Wang, Shujie;Wang, Yu;Cui, Hongliang;He, Xijun;Tu, Yabin;Wang, Gang;Cai, Xuehui;Yu, Ying

作者机构：

期刊名称：DISEASE MARKERS （ 影响因子：3.434； 五年影响因子：3.66 ）

ISSN： 0278-0240

年卷期： 2021 年 2021 卷

页码：

收录情况： SCI

摘要： The clinical outcome of porcine circovirus 3 (PCV3) infection is still controversial. Herein, a novel PCV3 isolate (PCV3-China/DB-1/2017) with the molecular characterization of 24A and 27K in the Cap protein was used to inoculate three-week-old cesarean-derived, colostrum-deprived piglets. The nine PCV3 DB-1 inoculated piglets exhibited no obvious clinical symptoms or macroscopic lesions. PCV3 displayed a broad histotropism, including the heart, liver, spleen, lung, kidney, brain, lymph nodes, and tonsil, and the lungs and lymph nodes contained a higher quantity of viral genomes compared to that of the other organs. From 7 days after PCV3 DB-1 inoculation, the piglets showed obvious IgG antibody responses against PCV3 rCap-VLPs. The cumulative results demonstrated that PCV3 trend to low pathogenicity.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序