Six Undescribed Capnosane-Type Macrocyclic Diterpenoids from South China Sea Soft Coral Sarcophyton crassocaule: Structural Determination and Biological Evaluation
文献类型： 外文期刊
第一作者： Peng, Hanyang
作者： Peng, Hanyang;Zeng, Yanbo;Wang, Hao;Chang, Wenjun;Chen, Huiqin;Dai, Haofu;Peng, Hanyang;Zeng, Yanbo;Wang, Hao;Chang, Wenjun;Chen, Huiqin;Dai, Haofu;Peng, Hanyang;Zhou, Fengjuan;Wang, Xiachang;Zeng, Yanbo;Chang, Wenjun
作者机构：
关键词： soft coral; Sarcophyton crassocaule; cembranoids; capnosane-type macrocyclic diterpenes; absolute configuration; anti-inflammation
期刊名称：MARINE DRUGS （ 影响因子：5.4； 五年影响因子：5.5 ）
ISSN：
年卷期： 2023 年 21 卷 12 期
页码：
收录情况： SCI
摘要： Six undescribed capnosane-type macrocyclic diterpenes sarcocrassolins A-F (1-6) and one related known analog pavidolide D (7) were isolated from Sarcophyton crassocaule, a soft coral collected off the Nansha Islands, in the South China Sea. Their complete structures, relative configurations and absolute configurations were established through comprehensive spectroscopic analysis, quantum mechanical nuclear magnetic resonance (QM-NMR) and single-crystal X-ray diffraction. Sarcocrassolins D (4) and E (5) showed inhibitory activity against lipopolysaccharide (LPS)-stimulated inflammatory responses in RAW264.7 cells with IC50 values of 76.8 +/- 8.0 mu M and 93.0 +/- 3.8 mu M, respectively.
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