5 '-tRF-GlyGCC promotes breast cancer metastasis by increasing fat mass and obesity-associated protein demethylase activity

文献类型： 外文期刊

第一作者： Chen, Fang

作者： Chen, Fang;Song, Chengchuang;Meng, Fantong;Zhu, Yuhua;Chen, Xi;Fang, Xingtang;Wang, Yanhong;Zhang, Chunlei;Song, Chengchuang;Chen, Xi;Fang, Xingtang;Wang, Yanhong;Zhang, Chunlei;Zhu, Yuhua;Ma, Daifu

作者机构：

关键词： 5?-tRF-GlyGCC; BC; m6A; Autophagy; Tumor metastasis

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.025； 五年影响因子：7.626 ）

ISSN： 0141-8130

年卷期： 2023 年 226 卷

页码：

收录情况： SCI

摘要： tRNA-derived fragments (tRFs) are a class of regulatory non-coding RNAs that play essential biological functions in cancer and stress-induced diseases. Several lines of evidence suggest that 5 '-tRF-GlyGCC participates in tumor progression; however, its molecular mechanisms remain unclear. In this study, we explored the function of 5 '- tRF-GlyGCC in breast cancer (BC) progression and studied the related potential molecular mechanisms. 5 '-tRF-GlyGCC expression increased in human BC, and it promoted the proliferation, migration, and invasion of BC cells in vitro and tumor growth and metastasis in vivo. 5 '-tRF-GlyGCC was found for the first time to bind directly to fat mass and obesity-associated proteins, and increase the activity of FTO demethylase, reducing eIF4G1 methyl-ation, inhibiting autophagy, and promoting BC proliferation and metastasis. These findings suggest that 5 '-tRF-GlyGCC might be a therapeutic target for treating BC.

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