Massive expansion of the pig gut virome based on global metagenomic mining

文献类型： 外文期刊

第一作者： Mi, Jiandui

作者： Mi, Jiandui;Jing, Xiaoping;Long, Ruijun;Ma, Chouxian;Yang, Yiwen;Li, Yong;Zhang, Yu;Zheng, Haixue

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期刊名称：NPJ BIOFILMS AND MICROBIOMES （ 影响因子：9.2； 五年影响因子：9.9 ）

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年卷期： 2024 年 10 卷 1 期

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收录情况： SCI

摘要： The pig gut virome plays a vital role in the gut microbial ecosystem of pigs. However, a comprehensive understanding of their diversity and a reference database for the virome are currently lacking. To address this gap, we established a Pig Virome Database (PVD) that comprised of 5,566,804 viral contig sequences from 4650 publicly available gut metagenomic samples using a pipeline designated "metav". By clustering sequences, we identified 48,299 viral operational taxonomic units (vOTUs) genomes of at least medium quality, of which 92.83% of which were not found in existing major databases. The majority of vOTUs were identified as Caudoviricetes (72.21%). The PVD database contained a total of 2,362,631 protein-coding genes across the above medium-quality vOTUs genomes that can be used to explore the functional potential of the pig gut virome. These findings highlight the extensive diversity of viruses in the pig gut and provide a pivotal reference dataset for forthcoming research concerning the pig gut virome.

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