Pea Peptide Modulates Abnormal Aβ Production in PC12 Cells Induced by Lead Exposure

文献类型： 外文期刊

第一作者： Li, Ning

作者： Li, Ning;Cui, Ningning;Bakry, Ibrahim A.;Ma, Yan;Cheng, Yongxia;Zhao, Guangshan;Yang, Huijie;Song, Lianjun;Qiao, Mingwu;Hai, Dan;Galaverna, Gianni;Huang, Xianqing

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关键词： Lead; Pea peptide; APP; BACE1; A beta(1-42); PI3K/AKT

期刊名称：PLANT FOODS FOR HUMAN NUTRITION （ 影响因子：3.6； 五年影响因子：4.1 ）

ISSN： 0921-9668

年卷期： 2025 年 80 卷 2 期

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收录情况： SCI

摘要： Lead (Pb) exposure poses significant health risks, particularly in neurodegenerative diseases such as Alzheimer's disease (AD). This study investigates the neuroprotective effects of pea peptide (PP4) on PC12 cells exposed to Pb. Using Cell Counting Kit-8 (CCK-8), pretreatment with PP4 at 50 and 200 mu M concentrations significantly improved cell viability compared to Pb-only treated cells (P < 0.05), indicating a protective effect. Moreover, Pb exposure led to increased Amyloid Precursor Protein (APP) expression at 10 and 20 mu M after 24 h (P < 0.05), while beta-site amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) levels were elevated across all concentrations tested (P < 0.05). We established that PP4 can mitigate Pb-induced cytotoxicity and reduce the expression of APP and BACE1 by activating the Phosphoinositide 3-kinase / Protein Kinase (PI3K/AKT) signaling pathway. This study highlights the potential of PP4 as a therapeutic agent in preventing neurotoxic damage associated with lead exposure, suggesting a novel approach for the management of AD.

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