Pea Peptides and Heavy Metal Neurotoxicity: Exploring Mechanisms and Mitigation Strategies in PC12 Cells
文献类型： 外文期刊
第一作者： Li, Ning
作者： Li, Ning;Cui, Ningning;Li, Tiange;Zhao, Peijun;Bakry, Ibrahim A.;Li, Qian;Cheng, Yongxia;Yang, Huijie;Galaverna, Gianni;Wang, Fangyu;Wang, Fangyu
作者机构：
关键词： Pea peptide; Calsyntenin-1; Lead; PC12; Alzheimer's disease
期刊名称：PLANT FOODS FOR HUMAN NUTRITION （ 影响因子：3.6； 五年影响因子：4.1 ）
ISSN： 0921-9668
年卷期： 2025 年 80 卷 1 期
页码：
收录情况： SCI
摘要： Calsyntenin-1 (Clst1) is a sensitive indicator of lead (Pb) toxicity in neural tissue. This study was designed to investigate the impact of lead exposure on Clst1 expression in PC12 cells and the mitigating effect of pea peptide 4 (PP4) on lead-induced neurotoxicity. Data showed that lead exposure, at varying doses and durations, disrupted the mRNA expression and protein levels of Clstn1 in PC12 cells. However, immunofluorescence results showed that treatment with PP4 significantly increased Clstn1 protein expression in the Pb + PP4 and PP4 groups compared to the Pb groups (P < 0.05). Lead exposure activates the JNK and p38 pathways; at the same time, PP4 treatment enhances ERK pathway activation and reduces JNK and p38 activation.
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