Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence

文献类型： 外文期刊

第一作者： Liu, Xiaoyan

作者： Liu, Xiaoyan;Liu, Yi;Liu, Junlin;Zhang, Hantao;Shan, Chaofan;Guo, Yinglu;Tang, Min;Liu, Yi;Gong, Xun;Cui, Mengmeng;Li, Xiubin

作者机构：

关键词： biomarker; diet pattern; gut microbiota; gut-brain axis; metagenomics; mitochondrial dysfunction; multi-omics; neurodegenerative disease; neuroinflammation; probiotic

期刊名称：NEURAL REGENERATION RESEARCH （ 影响因子：6.1； 五年影响因子：5.1 ）

ISSN： 1673-5374

年卷期： 2024 年 19 卷 4 期

页码：

收录情况： SCI

摘要： A growing body of evidence suggests that the gut microbiota contributes to the development of neurodegenerative diseases via the microbiota-gut-brain axis. As a contributing factor, microbiota dysbiosis always occurs in pathological changes of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. High-throughput sequencing technology has helped to reveal that the bidirectional communication between the central nervous system and the enteric nervous system is facilitated by the microbiota's diverse microorganisms, and for both neuroimmune and neuroendocrine systems. Here, we summarize the bioinformatics analysis and wet-biology validation for the gut metagenomics in neurodegenerative diseases, with an emphasis on multi-omics studies and the gut virome. The pathogen-associated signaling biomarkers for identifying brain disorders and potential therapeutic targets are also elucidated. Finally, we discuss the role of diet, prebiotics, probiotics, postbiotics and exercise interventions in remodeling the microbiome and reducing the symptoms of neurodegenerative diseases.

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