Meta-analysis and machine learning reveal the antiobesity effects of melatonin on obese rodents

文献类型： 外文期刊

第一作者： Li, Yuying

作者： Li, Yuying;Sun, Xihang;Wang, Mansheng;Jiang, Yayun;Ge, Qian Qian;Hou, Zhenping;Shi, Pengjun;Jiang, Yayun;Ge, Qian Qian;Yin, Jie;Li, Tiejun;Yao, Kang;Shi, Pengjun;Yao, Kang;Yin, Jie

作者机构：

关键词： lipid metabolism; machine learning; melatonin; meta-analysis; obesity mice; obesity rat

期刊名称：OBESITY REVIEWS （ 影响因子：8.9； 五年影响因子：9.8 ）

ISSN： 1467-7881

年卷期： 2024 年 25 卷 5 期

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收录情况： SCI

摘要： Melatonin appears to be a promising supplement for obesity treatment. The antiobesity effects of melatonin on obese rodents are influenced by various factors, including the species, sex, the dosage of melatonin, treatment duration, administration via, daily treatment time, and initial body weight (IBW). Therefore, we conducted a meta-analysis and machine learning study to evaluate the antiobesity effect of melatonin on obese mice or rats from 31 publications. The results showed that melatonin significantly reduced body weight, serum glucose (GLU), triglycerides (TGs), low-density lipoprotein (LDL), and cholesterol (TC) levels in obese mice or rats but increased high-density lipoprotein (HDL) levels. Melatonin showed a slight positive effect on clock-related genes, although the number of studies was limited. Meta-regression analysis and machine learning indicated that the dosage of melatonin was the primary factor influencing body weight, with higher melatonin dosages leading to a stronger weight reduction effect. Together, male obese C57BL/6 mice and Sprague-Dawley rats with an IBW of 100-200 g showed better body weight reduction when supplemented with a dose of 10-30 mg/kg melatonin administered at night via injection for 5-8 weeks.

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