The VP1 Protein of Porcine Teschovirus Inhibits the Innate Immune Response to Viral Infection by Blocking MDA5 Activation

文献类型： 外文期刊

第一作者： Li, Yuying

作者： Li, Yuying;Zhang, Xinyu;Zhao, Baopeng;Zhao, Chenchen;Lei, Xiaoxiao;Huang, Haixin;Li, Chengkai;Lan, Tian;Sun, Wenchao;Zheng, Min;Lu, Huijun

作者机构：

期刊名称：TRANSBOUNDARY AND EMERGING DISEASES （ 影响因子：4.3； 五年影响因子：4.3 ）

ISSN： 1865-1674

年卷期： 2024 年 2024 卷

页码：

收录情况： SCI

摘要： Porcine teschovirus (PTV) can cause reproductive dysfunction and respiratory diseases, with high mortality rates for sick pigs. Among Picornaviridae family virus-encoded proteins, the VP1 structural protein is critical for viral immune evasion. However, whether PTV VP1 inhibits the type I interferon (IFN) response remains unknown. Here, it shows that the PTV VP1 protein significantly hinders the activation of NF-kappa B, impairing Sendai virus-induced expression of beta IFN (IFN-beta). Further studies revealed that VP1 targets and interacts with the MDA5 factor in the RIG-I like receptors pathway. More importantly, the VP1 protein interacts with the caspase activation and recruitment domain and Hel domains of MDA5, blocking IFN-beta expression. Our findings provide evidence about the VP1 protein of PTV hinders MDA5 activation and may represent a viral mechanism to escape the innate immune response.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序