Adjuvant screening of the Senecavirus A inactivated vaccine in mice and evaluation of its immunogenicity in pigs

文献类型： 外文期刊

第一作者： Zhang, Jinyong

作者： Zhang, Jinyong;Li, Zhuoxin;Jin, Ningyi;Han, Jicheng;Zhang, Jinyong;Wang, Peng;Li, Zhuoxin;Xie, Yubiao;Jin, Ningyi;Zhang, He;Lu, Huijun;Han, Jicheng

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关键词： Senecavirus A (SVA); Inactive vaccine; Adjuvants; Protection efficacy

期刊名称：BMC VETERINARY RESEARCH （ 影响因子：2.6； 五年影响因子：2.9 ）

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年卷期： 2024 年 20 卷 1 期

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收录情况： SCI

摘要： BackgroundSenecavirus A (SVA) causes an emerging vesicular disease (VD) with clinical symptoms indistinguishable from other vesicular diseases, including vesicular stomatitis (VS), foot-and-mouth disease (FMD), and swine vesicular disease (SVD). Currently, SVA outbreaks have been reported in Canada, the U.S.A, Brazil, Thailand, Vietnam, Colombia, and China. Based on the experience of prevention and control of FMDV, vaccines are the best means to prevent SVA transmission.ResultsAfter preparing an SVA inactivated vaccine (CH-GX-01-2019), we evaluated the immunogenicity of the SVA inactivated vaccine mixed with Imject (R) Alum (SVA + AL) or Montanide ISA 201 (SVA + 201) adjuvant in mice, as well as the immunogenicity of the SVA inactivated vaccine combined with Montanide ISA 201 adjuvant in post-weaned pigs. The results of the mouse experiment showed that the immune effects in the SVA + 201 group were superior to that in the SVA + AL group. Results from pigs immunized with SVA inactivated vaccine combined with Montanide ISA 201 showed that the immune effects were largely consistent between the SVA-H group (200 mu g) and SVA-L group (50 mu g); the viral load in tissues and blood was significantly reduced and no clinical symptoms occurred in the vaccinated pigs.ConclusionsMontanide ISA 201 is a better adjuvant choice than the Imject (R) Alum adjuvant in the SVA inactivated vaccine preparation, and the CH-GX-01-2019 SVA inactivated vaccine can provide effective protection for pigs.

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