Advances in therapeutic and vaccine targets for Cryptosporidium: Challenges and possible mitigation strategies

文献类型： 外文期刊

第一作者： Mi, Rongsheng

作者： Mi, Rongsheng;Zhou, Shasha;Gong, Haiyan;Huang, Yan;Han, Xiangan;Chen, Zhaoguo;Ullah, Munib

作者机构：

关键词： Cryptosporidium; Diarrhea; Nitazoxanide; Vaccine targets; Mitigation plans

期刊名称：ACTA TROPICA （ 影响因子：3.222； 五年影响因子：3.095 ）

ISSN： 0001-706X

年卷期： 2022 年 226 卷

页码：

收录情况： SCI

摘要： Cryptosporidium is known to be the second most common diarrheal pathogen in children, causing potentially fatal diarrhea and associated with long-term growth stunting and cognitive deficits. The only Food and Drug Administration-approved treatment for cryptosporidiosis is nitazoxanide, but this drug has not shown potentially effective results in susceptible hosts. Therefore, a safe and effective drug for cryptosporidiosis is urgently needed. Cryptosporidium genome sequencing analysis may help develop an effective drug, but both in vitro and in vivo approaches to drug evaluation are not fully standardized. On the other hand, the development of partial im-munity after exposure suggests the possibility of a successful and effective vaccine, but protective surrogates are not precise. In this review, we present our current perspectives on novel cryptosporidiosis therapies, vaccine targets and efficacies, as well as potential mitigation plans, recommendations and perceived challenges.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序