文献类型： 外文期刊
第一作者： Yang, Mo
作者： Yang, Mo;Li, Zehou;Xu, Ying;Ji, Weiwei;Li, Xiaoxia;Wei, Jiayu;Zhou, Zhengrong;Ren, Minjie;Ma, Ke;Guan, Jiayu;Mo, Guoxiang;Zhang, Shuijun;Chen, Jing;Li, Yang;Wang, Meihua;Shu, Bo;Shi, Zheng-Li;Xu, Ran;Guo, Jingjing;Chen, Rong;Zhou, Peng;Yuan, Yuan
作者机构：
期刊名称：PLOS PATHOGENS （ 影响因子：4.9； 五年影响因子：5.4 ）
ISSN： 1553-7366
年卷期： 2024 年 20 卷 11 期
页码：
收录情况： SCI
摘要： Middle East respiratory syndrome coronavirus (MERS-CoV) and the pangolin MERS-like coronavirus MjHKU4r-CoV-1 employ dipeptidyl peptidase 4 (DPP4) as an entry receptor. MjHKU4r-CoV-1 could infect transgenic mice expressing human DPP4. To understand the mechanism of MjHKU4r-CoV-1 entry into cells, we determined the crystal structures of the receptor binding domain (RBD) of MjHKU4r-CoV-1 spike protein bound to human DPP4 (hDPP4) and Malayan pangolin DPP4 (MjDPP4), respectively. The overall hDPP4-binding mode of MjHKU4r-CoV-1 RBD is similar to that of MERS-CoV RBD. MjHKU4r-CoV-1 RBD shows higher binding affinity to hDPP4 compared to the bat MERS-like coronavirus Ty-BatCoV-HKU4. Via swapping residues between MjHKU4r-CoV-1 RBD and Ty-BatCoV-HKU4 RBD, we identified critical determinants on MjHKU4r-CoV-1 that are responsible for virus usage of hDPP4. Our study suggests that MjHKU4r-CoV-1 is more adapted to the human receptor compared to the bat HKU4 coronavirus and highlights the potential of virus emergence into the human population.
分类号：
- 相关文献
作者其他论文 更多>>
-
Identification of a functional vitamin D response element in the promoter of goose anti-Müllerian hormone gene
作者：Chen, Rong;Chen, Chen;Qin, Yifei;Liu, Jie;Lei, Mingming;Zhu, Huanxi;Shi, Zhendan;Chen, Rong;Chen, Chen;Qin, Yifei;Liu, Jie;Lei, Mingming;Zhu, Huanxi;Shi, Zhendan
关键词：Goose; Anti-M & uuml;llerian hormone; Vitamin D response element
-
The developments and prospects of plant super-pangenomes: Demands, approaches, and applications
作者：He, Wenchuang;Li, Xiaoxia;Qian, Qian;Shang, Lianguang;Qian, Qian;Shang, Lianguang;Qian, Qian;Qian, Qian;Shang, Lianguang
关键词：pangenomics; super-pangenome; plant; methodology; molecular breeding
-
Unraveling dual fusion mechanisms in BmNPV GP64: critical roles of CARC motifs and signal peptide retention
作者：Sun, Luping;Xu, Ying;Chen, Kai;Nan, Wenbin;Wang, Meixian;Zhang, Yiling;Hao, Bifang;Huang, Jinshan;Wang, Meixian;Zhang, Yiling;Hao, Bifang;Huang, Jinshan
关键词：BmNPV; GP64; baculovirus; CARC; membrane fusion; signal peptide
-
Arsenic Accumulation in Different Parent Materials of Rice (Oryza Sative L.) are Affected by Root Morphology
作者：Chen, Yi;Xu, Yinggang;Wu, Yueyi;Zeng, Zhaoyong;Tang, Xiaoyan;Li, Yang;Yan, Chaorui;Lan, Ting;Gao, Xuesong;Chen, Guangdeng;Li, Deqiang;Huang, Fu;Tu, Dehui
关键词：Rice; Root morphology; As accumulation; Correlation
-
Classical swine fever virus recruits ALIX and ESCRT-III to facilitate viral budding
作者：Chen, Jinxia;Yang, Hanfei;Wan, Mingyue;Cheng, Yan;Bai, Jishan;Li, Yuhang;Chen, Jing;Zhao, Bingqian;Zhou, Bin;Gao, Fei
关键词：CSFV; budding; ESCRT; ALIX; vesicle transport
-
Putative Transformation Mechanism of γ-
l -Glutamyl-S-Allyl-l -Cysteine during the Processing of Black Garlic作者：Liu, Pingxiang;Wu, Peng;Bi, Jingxiu;Jiang, Yuying;Gao, Rui;Zhao, Tong;Yuan, Xuexia;Hao, Haining;Wang, Yutao;Weng, Rui;Chen, Jing
关键词：gamma-l-glutamyl-S-allyl-l-cysteine; thermal processing; Maillard reaction; enzymatic hydrolysis; transformationmechanism
-
Salt stress-related function of the oil body-associated protein gene LcOBAP2B in Leymus chinensis
作者：Di, Dong;Zhang, Ran;Li, Xiaoxia;Qi, Dongmei;Li, Qian;Cheng, Liqin;Wu, Zinian
关键词：Leymus chinensis; LcOBAP2B; Salt tolerance
