A secreted glycerophosphodiester phosphodiesterase (GDPD) domain-containing protein, FpGDPD, is involved in Fusarium pseudograminearum virulence

文献类型： 外文期刊

第一作者： Liu, Min

作者： Liu, Min;Su, Zengqing;Zhang, Shiyu;Fan, Zhuo;Zhao, Peiyi;Xing, Xiaoping;Li, Honglian;Chen, Linlin;Su, Zengqing;Zhao, Wei;Li, Honglian;Chen, Linlin

作者机构：

关键词： Fusarium pseudograminearum; pathogenicity; plant defense; secreted protein

期刊名称：MYCOLOGIA （ 影响因子：2.6； 五年影响因子：2.7 ）

ISSN： 0027-5514

年卷期： 2025 年 117 卷 5 期

页码：

收录情况： SCI

摘要： Microbial pathogens secrete a diverse array of proteins to manipulate plant defense mechanisms and facilitate infection. However, few secreted proteins were thoroughly characterized in Fusarium pseudograminearum. Here, we identify and characterize FpGDPD, a gene encoding a secretory glycerophosphodiester phosphodiesterase (GDPD) domain-containing protein in F. pseudograminearum. We found that FpGDPD expression was significantly upregulated during specific stages of fungal infection. Disruption of FpGDPD in F. pseudograminearum did not affect vegetative growth, stress responses, or conidiation but enhanced phosphate tolerance and reduced fungal virulence in wheat. Furthermore, we demonstrated the secretory nature of the N-terminal signal peptide of FpGDPD and that the signal peptide contributes to F. pseudograminearum pathogenicity. Interestingly, FpGDPD triggers immune responses in Nicotiana benthamiana, inducing reactive oxygen species (ROS) accumulation and upregulating defense-related genes. Collectively, our findings reveal that FpGDPD plays a dual role: it promotes fungal virulence while simultaneously eliciting plant immune responses.

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