SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells

文献类型： 外文期刊

第一作者： Wang, Jinliang

作者： Wang, Jinliang;Wang, Xinxin;Wen, Zhiyuan;Shuai, Lei;Luo, Jie;Wang, Chong;Sun, Ziruo;Liu, Renqiang;Ge, Jinying;He, Xijun;Hua, Ronghong;Wang, Xijun;Chen, Weiye;Zhong, Gongxun;Bu, Zhigao;Yang, Guan;Yang, Xiao

作者机构：

期刊名称：CELL DISCOVERY （ 影响因子：38.079； 五年影响因子：19.649 ）

ISSN：

年卷期： 2021 年 7 卷 1 期

页码：

收录情况： SCI

摘要： Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses angiotensin-converting enzyme 2 (ACE2) as a binding receptor to enter cells via clathrin-mediated endocytosis (CME). However, receptors involved in other steps of SARS-CoV-2 infection remain largely unknown. Here, we found that metabotropic glutamate receptor subtype 2 (mGluR2) is an internalization factor for SARS-CoV-2. Our results show that mGluR2 directly interacts with the SARS-CoV-2 spike protein and that knockdown of mGluR2 decreases internalization of SARS-CoV-2 but not cell binding. Further, mGluR2 is uncovered to cooperate with ACE2 to facilitate SARS-CoV-2 internalization through CME and mGluR2 knockout in mice abolished SARS-CoV-2 infection in the nasal turbinates and significantly reduced viral infection in the lungs. Notably, mGluR2 is also important for SARS-CoV spike protein- and Middle East respiratory syndrome coronavirus spike protein-mediated internalization. Thus, our study identifies a novel internalization factor used by SARS-CoV-2 and opens a new door for antiviral development against coronavirus infection.

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