Identification of Host Molecules Involved in the Proliferation of Nucleopolyhedrovirus in Bombyx mori

文献类型： 外文期刊

第一作者： Xu, Jing

作者： Xu, Jing;Xie, Xiaole;Ma, Qiuqin;Zhang, Lu;Li, Yu;Chen, Yin;Li, Kang;Tian, Ling;Xu, Jing;Xu, Hanhong;Xu, Jing;Li, Kang;Xiao, Yang;Tettamanti, Gianluca;Tettamanti, Gianluca

作者机构：

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.895； 五年影响因子：6.048 ）

ISSN： 0021-8561

年卷期： 2022 年 70 卷 45 期

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收录情况： SCI

摘要： The Bombyx mori nucleopolyhedrovirus (BmNPV), a foodborne infectious virus, is the pathogen causing nuclear polyhedrosis and high lethality in the silkworm. In this study, we characterized the molecules involved in BmNPV-silkworm interaction by RNA sequencing of the fat body isolated from the virus-susceptible strain P50. Kyoto Encyclopedia of Genes and Genomes (KEGG) annotation showed that the upregulated differentially expressed genes (DEGs) were mainly involved in translation, signal transduction, folding, sorting, and degradation, as well as transport and catabolism, while the downregulated DEGs were predominantly enriched in the metabolism of carbohydrates, amino acids, and lipids at 72 h post BmNPV infection. Knockout of the upregulated somatomedin-B and thrombospondin type-1 domain-containing protein, probable allantoicase, trifunctional purine biosynthetic protein adenosine-3, and Psl and pyoverdine operon regulator inhibited the proliferation of BmNPV, while knockout of the downregulated clip domain serine protease 3 and carboxylesterase clade H, member 1 promoted it. The molecules herein identified provide a foundation for developing strategies and designing drugs against BmNPV. KEYWORDS: Bombyx mori, fat body, BmNPV, proliferation

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