Phenotype of White Sika Deer Due to SCF Gene Structural Variation
文献类型: 外文期刊
第一作者: Chen, Xu
作者: Chen, Xu;Dong, Shiwu;Ding, Ning;Xing, Xiumei;Chen, Xu;Liu, Xin;Ding, Ning
作者机构: Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, State Key Lab Mol Biol Special Econ Anim, Changchun 130112, Peoples R China;Northeast Forestry Univ, Coll Wildlife & Protected Area, Harbin 150040, Peoples R China
关键词: SCF; sika deer; whole-genome sequencing; melanin
期刊名称:GENES ( 2022影响因子:3.5; 五年影响因子:3.9 )
年卷期: 2023 年 14 卷 5 期
收录情况: SCI
摘要: Breeding ornamental white sika deer is a new notion that can be used to broaden the sika deer industry However, it is very rare for other coat phenotypes to occur, especially white (apart from albinism), due to the genetic stability and homogeneity of its coat color phenotype, making it difficult to breed white sika deer between species. We found a white sika deer and sequenced its whole genome. Then, the clean data obtained were analyzed on the basis of gene frequency, and a cluster of coat color candidate genes containing 92 coat color genes, one SV (structure variation), and five nonsynonymous SNPs (single nucleotide polymorphisms) was located. We also discovered a lack of melanocytes in the skin tissue of the white sika deer through histological examination, initially proving that the white phenotype of sika deer is caused by a 10.099 kb fragment deletion of the SCF gene(stem cell factor). By designing SCF-specific primers to detect genotypes of family members of the white sika deer, and then combining them with their phenotypes, we found that the genotype of the white sika deer is SCF789/SCF789, whereas that of individuals with white patches on their faces is SCF789/SCF1-9. All these results showed that the SCF gene plays an important role in the development of melanocytes in sika deer and is responsible for the appearance of the white coat color. This study reveals the genetic mechanism of the white coat color in sika deer and supplies data as a reference for breeding white ornamental sika deer.
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