Regulation of plant immunity through histone H3 β-hydroxybutyrylation-mediated transcriptional control

文献类型： 外文期刊

第一作者： Xu, Qiutao

作者： Xu, Qiutao;Zhang, Jisen;Chen, Zhengting;Rui, Wang;Ma, Xuan;Duan, Yuhang;Hai, Du;Zheng, Lu;Huang, Junbin;Chen, Jing;Chen, Xiaoyang;Cheng, Zhongyi;Zhao, Yu

作者机构：

期刊名称：NATURE COMMUNICATIONS （ 影响因子：15.7； 五年影响因子：17.2 ）

ISSN：

年卷期： 2025 年 16 卷 1 期

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收录情况： SCI

摘要： Histone lysine beta-hydroxybutyrylation (Kbhb) is a novel type of histone acylation whose prevalence and function remain unclear in plants. Here, we systematically characterized H3K9bhb in rice (Oryza sativa) and found that it is enriched at transcription start site (TSS) regions and serves as an active mark for gene expression. We demonstrated functional differences between H3K9bhb and the well-studied H3K9ac histone modification, particularly in regulating genes involved in the rice immune response. We also discovered that the exogenous application of beta-hydroxybutyrate induces H3K9bhb deposition and promotes the expression of defense-related genes, enhancing disease resistance. Furthermore, we identified OsSRT1, OsSRT2, and OsHDA705 as key players in the removal of Kbhb. We also conducted a Kbhb proteomic analysis and identified 2159 Kbhb sites on 1128 proteins, providing a valuable resource for future studies of Kbhb. This research advances our understanding of plant epigenetic regulation by establishing Kbhb as a cellular post-translational modification with the potential to regulate plant immune responses.

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