Fluoride induced leaky gut and bloom of Erysipelatoclostridium ramosum mediate the exacerbation of obesity in high-fat-diet fed mice

文献类型： 外文期刊

第一作者： Chen, Guijie

作者： Chen, Guijie;Peng, Yujia;Huang, Yujie;Dong, Wei;Xu, Weiqi;Xie, Zhiyong;Chen, Dan;Fan, Xia;Zhou, Wangting;Kan, Xuhui;Yang, Tingting;Chen, Chunxu;Sun, Yi;Zeng, Xiaoxiong;Xie, Minhao;Dai, Zhuqing;Cai, Huimei;Liu, Zhonghua;Liu, Zhonghua

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关键词： Fluoride; Exacerbation of obesity; Intestinal barrier permeability; Gut microbiota; Erysipelatoclostridium ramosum

期刊名称：JOURNAL OF ADVANCED RESEARCH （ 影响因子：10.7； 五年影响因子：11.4 ）

ISSN： 2090-1232

年卷期： 2023 年 50 卷

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收录情况： SCI

摘要： Introduction: Fluoride is widely presented in drinking water and foods. A strong relation between fluoride exposure and obesity has been reported. However, the potential mechanisms on fluoride-induced obesity remain unexplored. Objectives and methods The effects of fluoride on the obesity were investigated using mice model. Furthermore, the role of gut homeostasis in exacerbation of the obesity induced by fluoride was evaluated. Results The results showed that fluoride alone did not induce obesity in normal diet (ND) fed mice, whereas, it could trigger exacerbation of obesity in high-fat diet (HFD) fed mice. Fluoride impaired intestinal barrier and activated Toll-like receptor 4 (TLR4) signaling to induce obesity, which was further verified in TLR4(-/-) mice. Furthermore, fluoride could deteriorate the gut microbiota in HFD mice. The fecal micro biota transplantation from fluoride-induced mice was sufficient to induce obesity, while the exacerbation of obesity by fluoride was blocked upon gut microbiota depletion. The fluoride-induced bloom of Erysipelatoclostridium ramosum was responsible for exacerbation of obesity. In addition, a potential strategy for prevention of fluoride-induced obesity was proposed by intervention with polysaccharides from Fuzhuan brick tea. Conclusion Overall, these results provide the first evidence of a comprehensive cross-talk mechanism between fluoride and obesity in HFD fed mice, which is mediated by gut microbiota and intestinal barrier. E. ramosum was identified as a crucial mediator of fluoride induced obesity, which could be explored as potential target for prevention and treatment of obesity with exciting translational value. (c) 2023 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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