Secondary Metabolites of Fomitopsis betulina: Chemical Structures, Biological Activity and Application Prospects

文献类型： 外文期刊

第一作者： Li, Jianghao

作者： Li, Jianghao;Li, Ziheng;Duan, Yingce;Liu, Chengwei;Yan, Meixia

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关键词： Fomitopsis betulina; secondary metabolites; cultivation; terpenoids; biosynthesis

期刊名称：JOURNAL OF FUNGI （ 影响因子：4.0； 五年影响因子：4.5 ）

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年卷期： 2024 年 10 卷 9 期

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收录情况： SCI

摘要： Fomitopsis betulina, as a macrofungus with both medicinal and dietary applications, is renowned for its rich content of bioactive substances. The recent advancements in research have significantly enhanced our understanding of its polysaccharides, cellulose-degrading enzymes, and wide range of secondary metabolites. This paper provides a comprehensive review of the artificial cultivation techniques and the chemical profiling of over 100 secondary metabolites identified in F. betulina, including terpenoids, phenols, and various other classes. These compounds exhibit notable pharmacological activities, such as anti-cancer, anti-inflammatory, antimicrobial, antiviral, and anti-malarial effects. Moreover, this review delves into the genomic analysis of F. betulina, focusing on the prediction and classification of terpene synthases, which play a crucial role in the biosynthesis of these bioactive compounds. This insight is instrumental for potentially facilitating future biochemical studies and pharmaceutical applications. Through this review, we aim to solidify the foundation for future in-depth studies and the development of new drugs derived from this promising natural resource.

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